Endocrine Abstracts

Genetic variants consistently associated with the development of Graves’ disease (GD) have, to date, been general autoimmunity loci including those within the HLA region, the CTLA-4 gene and most recently the PTPN22 gene encoding lymphoid tyrosine phosphatase (LYP). The thyrotophin receptor gene (TSHR) has recently however, been identified as the first Graves’ disease specific susceptibility locus. To further refine association with disease and exclude populat...